PULMONARY

CAPSULE FILLING FOR DPIs – LINKING PROCESS SCALES THROUGH ADVANCED CHARACTERISATION AND QUALITY BY DESIGN

Rui Churro, Carolina Lopes and João Pires discuss the value of rheological characterisation of powders to expedite and de-risk the scale-up of DPI capsule-filling processes.

A ROADMAP FOR DRUG-NEBULISER COMBINATION PRODUCT DEVELOPMENT

Edgar Hernan Cuevas Brun and Yuan-Ming Hsu lay out HCmed Innovations’ roadmap for the development of drug-nebuliser combination products.

NAVIGATING pMDI REFORMULATION 2.0

NAVIGATING pMDI REFORMULATION 2.0

Chris Baron and William Ganley examine possible responses to the environmental impact of pressurised metered dose inhalers use and consider alternative inhaler types, with a focus on the strategies and support that can accelerate the development of the next generation of pMDIs.

THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES

Dr Marie-Christine Klein

THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES

Marie-Christine Klein, Andreas Bilstein and Caroline Hoffmann discuss the underlying techniques involved in the use of metered pump-based soft mist devices and their application diversity.

NOVEL INDUSTRIAL-SCALE ELECTROSTATIC CHARGE ELIMINATION METHOD FOR INHALATION PRODUCTS

Dr Orest Lastow

NOVEL INDUSTRIAL-SCALE ELECTROSTATIC CHARGE ELIMINATION METHOD FOR INHALATION PRODUCTS

Orest Lastow describes a novel technique for removing the built-up charge from dry powder inhaler components, offering a potential solution to the issues caused by static charges in these devices, including decreased performance, altered powder properties and increased variability in delivered dose.

DEVELOPMENT APPROACH FOR A HIGH-PERFORMANCE CAPSULE-BASED DPI

Dr Mirjam Kobler

DEVELOPMENT APPROACH FOR A HIGH-PERFORMANCE CAPSULE-BASED DPI

Mirjam Kobler, Ameet Sule and Sunita Sule look at the factors affecting the performance of dry powder inhalers and discuss the company’s development of high-performance prototypes.

ARE YOU STRUGGLING TO PUT DIFFICULT POWDERS INTO CAPSULES?

ARE YOU STRUGGLING TO PUT DIFFICULT POWDERS INTO CAPSULES?

Andy Cleall and Ben Smith discuss process optimisation and cutting-edge technology for powder filling, including how 3P’s R500 and R1000 robotic capsule fillers are pushing the boundaries of optimal filling and how its Fill2Weight technology enables increased filling accuracy and improved yields.

ISOTHERMAL DRY PARTICLE COATING – BACK TO THE FUTURE?

Dr Jasdip Koner

Aston Particle Technologies

ISOTHERMAL DRY PARTICLE COATING – BACK TO THE FUTURE?

Jasdip Koner, Abdul Ershad and David Wyatt introduce Aston Particle Technologies’ novel dry powder processing technology – isothermal dry particle coating (iDPC™) – explaining how it has the capacity to enhance and broaden the scope of what dry powder formulations can achieve in respiratory medicine.

DUE DILIGENCE – THE KEY TO SUCCESS IN DRUG DELIVERY DEVICE SELECTION

DUE DILIGENCE – THE KEY TO SUCCESS IN DRUG DELIVERY DEVICE SELECTION

Matt Jones and Rob Veasey consider the process of matching the drug with the right delivery device and look at the importance of due diligence when “licensing in” technology.

CONSIDERATIONS WHEN SWITCHING FROM CURRENT pMDI PROPELLANTS TO NEW LOWER-GWP PROPELLANTS

CONSIDERATIONS WHEN SWITCHING FROM CURRENT pMDI PROPELLANTS TO NEW LOWER-GWP PROPELLANTS

Mark Parry discusses the considerations that need to be made when switching from current pressurised metered dose inhaler propellants to new alternatives with lower global warming potential, including formulation, regulatory and analytical standpoints.

ADVANCEMENTS IN MONITORING ADHERENCE – A SMART MESH NEBULISER

Edgar Hernan Cuevas Brun

HCmed Innovations

ADVANCEMENTS IN MONITORING ADHERENCE – A SMART MESH NEBULISER

Edgar Hernan Cuevas Brun and Yuan-Ming Hsu consider patient adherence and the role HCmed Innovations’ AdheResp mesh nebuliser plays in monitoring adherence.

DIGITAL HEALTH: ADDRESSING MODERN HEALTHCARE CHALLENGES WITH SENSORS

Dr Haykel Ben Jamaa

DIGITAL HEALTH: ADDRESSING MODERN HEALTHCARE CHALLENGES WITH SENSORS

Haykel Ben Jamaa explores why modern society needs digital health and how it is organised and implemented, with a focus on sensing technologies empowering digital health technologies.

WHY ARE INHALATION DEVICES SO DIFFICULT TO DEVELOP?

Dr Orest Lastow

WHY ARE INHALATION DEVICES SO DIFFICULT TO DEVELOP?

Orest Lastow discusses the challenges of developing inhalation products and how best to keep costs down and prevent project delays.

CREATING A PLATFORM FOR NEBULISATION OF A WIDE RANGE OF DRUG TYPES AND FORMULATIONS

Dr Elijah Nazarzadeh

CREATING A PLATFORM FOR NEBULISATION OF A WIDE RANGE OF DRUG TYPES AND FORMULATIONS

Elijah Nazarzadeh and John Pritchard introduce Nebu~Flow – a novel class of nebuliser technology that represents a major step in the ability to deliver drugs efficiently to the lungs. overcoming the limitations of current systems and unlocking the potential of the inhalation route, including for systemic delivery.

AN AIRLESS SPRAY NOZZLE TO PRODUCE A FINE AND SOFT MIST

Dr Claire Authesserre

AN AIRLESS SPRAY NOZZLE TO PRODUCE A FINE AND SOFT MIST

Claire Authesserre and Florian Corne discuss the current challenges faced by the topical spray-based delivery of therapeutics and how EVEON’s Ad-Mist™ spray nozzle overcomes these challenges to harness the potential of this delivery route.

GETTING A GRIP ON FRICTION – A CRUCIAL CONSIDERATION FOR INHALER DESIGN

GETTING A GRIP ON FRICTION – A CRUCIAL CONSIDERATION FOR INHALER DESIGN

Bryan Deacon discusses the importance of considering friction when developing a new inhaler design, providing an overview of some of the basic considerations friction raises, as well as highlighting how optimising friction early with the aid of a materials expert can reduce risk, lower cost and lead to a better product overall.

EXPLORING NEW IN VITRO TESTS TO DEMONSTRATE BIOEQUIVALENCE IN INHALATION PRODUCTS

Proveris Scientific

EXPLORING NEW IN VITRO TESTS TO DEMONSTRATE BIOEQUIVALENCE IN INHALATION PRODUCTS

Proveris Scientific looks at recent advances in in vitro testing in inhalation products to demonstrate bioequivalence and discusses the company’s INVIDA platform that replicates human usage of the device.

EXPANDING THE DESIGN OF CHARACTERISATION STUDIES FOR ACCURATE HANDLING-ERROR ASSESSMENT

Dr Yannick Baschung

EXPANDING THE DESIGN OF CHARACTERISATION STUDIES FOR ACCURATE HANDLING-ERROR ASSESSMENT

Yannick Baschung discusses the importance of a comprehensive and accurate assessment of patient handling errors when it comes to inhaled product development.

THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION

THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION

James Silk discusses the importance of accounting for uncertainty when characterising the extractables profile of a medication, with particular reference to the ISO 10993 standard.

POWDER CHARACTERISATION FOR DPI PERFORMANCE IN CAPSULE-BASED INHALERS

Dr Salvatore Pillitteri

POWDER CHARACTERISATION FOR DPI PERFORMANCE IN CAPSULE-BASED INHALERS

Salvatore Pillitteri, Aurélien Neveu and Sarah Zellnitz-Neugebauer discuss the analysis of three powder blends of salbutamol sulphate with distinct lactose grades, using tapped density and rotating drum methods.

DELIVERING BIOLOGICS WITH SOFT MIST INHALERS – A MARKET POISED TO EXPAND

Dr Philippe Rogueda

DELIVERING BIOLOGICS WITH SOFT MIST INHALERS – A MARKET POISED TO EXPAND

Philippe Rogueda discusses the inhalable biologics market, how the introduction of soft mist inhalers represents a significant opportunity for new and old therapeutics alike, and how the market is poised for a major expansion in therapeutic application, size and value.

ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE

INDUSTRIALISATION

Drew Jelgerhuis

Scherdel Medtec North America

ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE

Drew Jelgerhuis looks at how a design-for-excellence (DFX) systematic approach can help manufacturers achieve their objectives.

HIGH-PRECISION INJECTION MOULDS FOR INHALERS: CHALLENGES AND SOLUTIONS

INDUSTRIALISATION

HIGH-PRECISION INJECTION MOULDS FOR INHALERS: CHALLENGES AND SOLUTIONS

Rob Doorakkers and Erwin van Huijksloot discuss the challenges and solutions of engineering and manufacturing high-precision injection moulds for inhalers.

CLIPhaler – INHALATION DEVICE DESIGN REDUCED TO THE MAXIMUM

Dr Klaus-Dieter Beller

CLIPhaler – INHALATION DEVICE DESIGN REDUCED TO THE MAXIMUM

Klaus-Dieter Beller discusses the advantages of the inhalation route of administration, how his principle of design simplicity has informed the design of novel inhalation devices and introduces CLIPhaler, his latest and simplest device.

THE INNOVATIONS TACKLING CHALLENGES & MAXIMISING OPPORTUNITIES IN INHALATION

THE INNOVATIONS TACKLING CHALLENGES & MAXIMISING OPPORTUNITIES IN INHALATION

Marco Franza and Nadine Khoury look at how the latest digital technologies, manufacturing techniques and packaging materials are combining to take the manufacture of inhalers to a new level.

TAKING THE STING OUT OF VACCINES

Dr Heather Jameson

TAKING THE STING OUT OF VACCINES

Heather Jameson, Juliette Ngan and Omar Shah discuss the potential advantages and challenges of intranasal and inhaled vaccines in the context of global respiratory pandemics.

SOLVING COMPLEX FORMULATION & DELIVERY CHALLENGES FOR INTRANASAL DRUGS

SOLVING COMPLEX FORMULATION & DELIVERY CHALLENGES FOR INTRANASAL DRUGS

Paul Kippax discusses the analytical techniques used for in vitro characterisation of nasal sprays, and how their use can accelerate and de-risk both innovator and generic nasal drug development.

MAKING SUSTAINABILITY BY DESIGN THE LINTEL OF SUSTAINABLE INHALER DEVELOPMENT

MAKING SUSTAINABILITY BY DESIGN THE LINTEL OF SUSTAINABLE INHALER DEVELOPMENT

Phil Seeney, Philip Winkworth and Craig Nelson provide an insight into sustainability developments in the pharmaceutical industry, with a focus on inhalables.

CONSIDERING THE SUSTAINABILITY IMPACT OF CONNECTED INHALERS IN THE TREATMENT OF ASTHMA

Dr Iain Simpson

Phillips-Medisize

CONSIDERING THE SUSTAINABILITY IMPACT OF CONNECTED INHALERS IN THE TREATMENT OF ASTHMA

Iain Simpson and Vinith Bhandari consider the sustainability impact of device connectivity specific to asthma inhalers through the reduction of greenhouse gas emissions.

SUSTAINABILITY MEASURES ARE THE KEY TO MEETING ESG COMMITMENTS

Matthias Birkhoff

SUSTAINABILITY MEASURES ARE THE KEY TO MEETING ESG COMMITMENTS

Matthias Birkhoff and Christophe Marie discuss the advances Aptar Pharma has made in delivering on its sustainability objectives.

INDUSTRIALISATION AND SCALE-UP OF DRUG DELIVERY DEVICES

INDUSTRIALISATION

Dr Barry McDermott

West Pharmaceutical Services

INDUSTRIALISATION AND SCALE-UP OF DRUG DELIVERY DEVICES

Barry McDermott and Shari Krusniak look at the manufacturing processes involved in bringing a new drug delivery system and formulation to market.

HOLISTIC DEVELOPMENT & INDUSTRIALISATION OF DRUG DELIVERY DEVICES & COMBINATION PRODUCTS

INDUSTRIALISATION

HOLISTIC DEVELOPMENT & INDUSTRIALISATION OF DRUG DELIVERY DEVICES & COMBINATION PRODUCTS

Mark Tunkel and Niyati Sapatnekar discuss Nemera’s holistic approach to development and industrialisation.

THE SMART INHALER REVOLUTION: ARE WE THERE YET?

Cambridge Design Partnership

THE SMART INHALER REVOLUTION: ARE WE THERE YET?

Mark Allen, David Blakey and Karla Sanchez discuss the benefits of smart inhalers and how they could influence the commercialisation of respiratory drugs in the future.

ARE GOVERNMENTS BANNING THE MOST ENVIRONMENTALLY FRIENDLY INHALER?

ARE GOVERNMENTS BANNING THE MOST ENVIRONMENTALLY FRIENDLY INHALER?

Rob Udale, Catriona Eldridge and Omar Shah assess the assertion that pMDIs are the most environmentally damaging of the available pulmonary drug delivery device archetypes, and explore some of the intricacies not accounted for in the public discourse surrounding pMDIs.

SMART SOLUTIONS TO REDUCE CARBON FOOTPRINT

SMART SOLUTIONS TO REDUCE CARBON FOOTPRINT

Rob Doorakkers and Geert van Amstel discuss why the company decided to become carbon neutral, how it is working to make injection moulding more sustainable and how the organisation is minimising its impact on the environment.

DESIGNING DRUG DELIVERY DEVICES TO MEET EMERGING NEEDS AND SUSTAINABILITY GOALS

Dr Pierre Moulinie

DESIGNING DRUG DELIVERY DEVICES TO MEET EMERGING NEEDS AND SUSTAINABILITY GOALS

Pierre Moulinié, Isaac Platte and Lauren Zetts discuss how polycarbonate-based materials deliver value to emerging drug delivery devices.

HOW CAN THE PHARMA INDUSTRY PREPARE FOR NEW pMDI PROPELLANTS?

HOW CAN THE PHARMA INDUSTRY PREPARE FOR NEW pMDI PROPELLANTS?

Nick Atkinson looks at the changes that are set to hit pressurised metered dose inhaler manufacturing as new propellants are introduced and how pharma companies can prepare for the switch.

CAPSULES: CLASSIC DRUG DELIVERY FORM HOLDS POTENTIAL FOR SUSTAINABLE DELIVERY

Dr Jnanadeva Bhat

CAPSULES: CLASSIC DRUG DELIVERY FORM HOLDS POTENTIAL FOR SUSTAINABLE DELIVERY

Jnanadeva Bhat and Anita Solanki discuss the role that hard capsules are able to play in delivering a more sustainable pharmaceutical industry, both as an oral solid dosage form and in dry powder inhalers.

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