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PREFILLED SYRINGES

OCULAR
OPTIMISING MICROLITRE DOSING: CASE STUDY WITH INTRAVITREAL INJECTION
Yuki Takeuchi and Richard Whelton discuss the challenges of delivering intravitreal injections and how the combination of Terumo’s PLAJEX™ prefillable syringes with Congruence’s Microlitre Dosing Syringe system is able to address them.
PREFILLED SYRINGES
OXYCAPT: SUPERIOR PRIMARY CONTAINERS FOR BIOLOGICS AND GENE AND CELL THERAPIES
Yasuaki Yoshimura and Tomohiro Suzuki review the advantages that OXYCAPT, the company’s multilayer material for vials, offers to biologics and gene and cell therapies, and discuss the results of recent tests into low temperature storage and dimethyl sulfoxide resistance.
INTRAVITREAL INJECTIONS – MORE THAN MEETS THE EYE: A TECHNICAL VIEW OF PRODUCT USE
OCULAR
Dr Andrea Allmendinger
ten23 health
INTRAVITREAL INJECTIONS – MORE THAN MEETS THE EYE: A TECHNICAL VIEW OF PRODUCT USE
Andrea Allmendinger and Hanns-Christian Mahler highlight the technical challenges of intravitreal administration and considerations from the ophthalmologist’s and patient’s perspectives.
PATIENT-CENTRIC DESIGN CAN BE A FASTER PATH TO MARKET
INJECTION
Dr Brent Buchine
Windgap Medical
PATIENT-CENTRIC DESIGN CAN BE A FASTER PATH TO MARKET
Brent Buchine considers a faster path to market for automated and easy-to-use reconstitution devices through simplification of the delivery systems.
OPPORTUNITIES FOR INNOVATION WITH BIOSIMILARS
PREFILLED SYRINGES
Dr Iain Simpson
Phillips-Medisize
OPPORTUNITIES FOR INNOVATION WITH BIOSIMILARS
Iain Simpson and George Spooner investigate the use of drug delivery systems that support self-administration of biologic drugs, and specifically biosimilars, for the treatment of chronic diseases. This article is based on research conducted by both authors as part of the MPhil in Therapeutic Sciences at the University of Cambridge (UK) and supported by Phillips-Medisize.
Pro-Tects – A NOVEL SOLUTION TO THE CHALLENGE OF BIOLOGIC INSTABILITY
INJECTION
Dr Shane Smith
Glycome BioPharma
Pro-Tects – A NOVEL SOLUTION TO THE CHALLENGE OF BIOLOGIC INSTABILITY
Shane Smith, Eoin Scanlan and Paula Colavita discusses the difficulty inherent in developing parenteral biologic products due to the challenge of creating a stable formulation in the face of surface-mediated protein aggregation and introduces Pro-Tects – Glycome’s patented surface-treatment technology platform that offers a solution to this critical issue without introducing further development challenges.
PRODUCT SHOWCASE: New Requirements for Injection Devices Make Advanced Testing Solutions Necessary
INDUSTRIALISATION
Peter Schmidt
ZwickRoell
PRODUCT SHOWCASE: New Requirements for Injection Devices Make Advanced Testing Solutions Necessary
ZwickRoell showcases its advanced testing solutions for injection devices including pens, autoinjectors and on-body delivery systems.
Interview: Kymanox Executive Advisors Mathias Romacker, Fran DeGrazio & Paul Jansen
INTERVIEW
Guy Furness
Kymanox
Interview: Kymanox Executive Advisors Mathias Romacker, Fran DeGrazio & Paul Jansen
Mathias Romacker, Fran DeGrazio and Paul Jansen sit down with Guy Furness, to discuss what it is that has driven Kymanox’s rapid rise in the drug delivery space and what makes the consulting company’s model so successful, as well as to share their expertise on a variety of topics in an illuminating discussion, including connectivity, how large and small drug developers engage with consultancies, 5 mL autoinjectors and the interface between drug primary packaging and delivery devices.
SILICONE-OIL-FREE PREFILLED SYRINGE SYSTEMS – GUIDANCE FOR SELECTING THE APPROPRIATE PACKAGING MATERIALS AND FOR SILICONISATION
PREFILLED SYRINGES
Bernd Zeiss
Gerresheimer
SILICONE-OIL-FREE PREFILLED SYRINGE SYSTEMS – GUIDANCE FOR SELECTING THE APPROPRIATE PACKAGING MATERIALS AND FOR SILICONISATION
Bernd Zeiss addresses the influence of silicone oil on syringe systems and highlights the advantages and possibilities of novel silicone-oil-free prefillable syringes, both for glass and for plastic syringes.
Interview: Gabriel Zenker, Aptar Pharma
INTERVIEW
Guy Furness
Aptar Pharma
Interview: Gabriel Zenker, Aptar Pharma
Gabriel Zenker talks with ONdrugDelivery about Aptar Pharma’s ambitions for the parenterals sector. Mr Zenker explains how Aptar, already a major player in the pulmonary, nasal, ophthalmic and dermal markets, is undertaking a major expansion of its facilities, boosting the company’s capacity, capabilities and technologies, to provide its extensive service and product offering to the exciting injectables space.
ACCELERATING NOVEL THERAPIES TO THE CLINIC – CUSTOM SOLUTIONS
PREFILLED SYRINGES
Asmita Khanolkar
SMC Ltd
ACCELERATING NOVEL THERAPIES TO THE CLINIC – CUSTOM SOLUTIONS
Asmita Khanolkar discusses the key offerings necessary to accelerate “speed to clinic” for custom manufacturing solutions.
ANTICIPATING & MITIGATING CHALLENGES IN THE COMMERCIALISATION OF PREFILLED SYRINGES & INJECTION DEVICES – A TECHNICAL DRUG PRODUCT PERSPECTIVE
PREFILLED SYRINGES
Dr Andrea Allmendinger
ten23 health
ANTICIPATING & MITIGATING CHALLENGES IN THE COMMERCIALISATION OF PREFILLED SYRINGES & INJECTION DEVICES – A TECHNICAL DRUG PRODUCT PERSPECTIVE
Andrea Allmendinger and Hanns-Christian Mahler both at ten23 health, provide an insight into the challenges of integrated development of drug product and device design and fill-finish manufacturing operations.
A TALE OF TWO SPRINGS
PREFILLED SYRINGES
Sebastian Block
Scherdel Medtec North America
A TALE OF TWO SPRINGS
Sebastian Block and Drew Jelgerhuis introduce two types of springs and highlight their important role in drug delivery devices.
ENGINEERING ADVANCES IN NEEDLE GEOMETRY TO ACCOMMODATE VISCOUS BIOLOGICS
INJECTION
Silvia Gallina
Stevanato Group
ENGINEERING ADVANCES IN NEEDLE GEOMETRY TO ACCOMMODATE VISCOUS BIOLOGICS
Silvia Gallina discusses the challenges faced in administering highly viscous biologics to patients via subcutaneous injection, and how Stevanato Group’s new special thin-wall needles are able to tackle them.
BEING PREPARED FOR PHARMA INNOVATION IS KEY IN 2023
INJECTION
Victoria Morgan
West Pharmaceutical Services
BEING PREPARED FOR PHARMA INNOVATION IS KEY IN 2023
Victoria Morgan and Ana Marques Kuschel discuss three recent innovations that West Pharmaceutical Services has introduced to enable its partners to respond to specific market-driven challenges, from pandemic-driven pressures on fill-finish productivity to the underlying shift towards biologics and the accelerated growth of home-based treatment.
AREAS TO WATCH IN CONNECTED DRUG DELIVERY DEVICE DEVELOPMENT
CONNECTIVITY
Michael Earl
Owen Mumford
AREAS TO WATCH IN CONNECTED DRUG DELIVERY DEVICE DEVELOPMENT
Michael Earl identifies areas of development in the field of connected drug delivery devices, providing an insight into what can be expected in the coming years. He draws on Owen Mumford’s own research, as well as discussions with industry experts and counterparts.
THE NEW YPSOMATE™ 5.5 – TAKING HANDHELD SELF-INJECTION BEYOND VOLUMES OF 2 ML
INJECTION
Reto Jost
Ypsomed
THE NEW YPSOMATE™ 5.5 – TAKING HANDHELD SELF-INJECTION BEYOND VOLUMES OF 2 ML
Reto Jost introduces YpsoMate 5.5, the staked-needle-syringe-based, two-step autoinjector for injection volumes in the 2.0–5.5 mL range, and discusses the drivers of the demand for high-volume, high-rate subcutaneous drug delivery using handheld autoinjectors.
INDUSTRIALISATION OF CUSTOMISABLE PRODUCT PLATFORMS IN LIFE SCIENCES
INDUSTRIALISATION
Umit Ismail Tsavous
teamtechnik
INDUSTRIALISATION OF CUSTOMISABLE PRODUCT PLATFORMS IN LIFE SCIENCES
Umit Ismail Tsavous, Carsten Köhler and Tom Nägele discuss customisation of product platforms in the life sciences field.
DEVELOPING, MANUFACTURING AND DELIVERING A FILL-FINISH PILOT LINE FOR TUB-BASED PREFILLED SYRINGES
INDUSTRIALISATION
Jake Canner
3P Innovation
DEVELOPING, MANUFACTURING AND DELIVERING A FILL-FINISH PILOT LINE FOR TUB-BASED PREFILLED SYRINGES
Jake Canner discusses the latest project arising out of 3P innovation’s partnership with Cambridge Pharma and its sister company Oval Medical Technologies – including the challenges involved and how they were overcome.
ADVANCED DELIVERY DEVICE TECHNOLOGY TO SIMPLIFY THE RECONSTITUTION OF LYOPHILISED DRUGS
INJECTION
Dr Fred Metzmann
Haselmeier
ADVANCED DELIVERY DEVICE TECHNOLOGY TO SIMPLIFY THE RECONSTITUTION OF LYOPHILISED DRUGS
Fred Metzmann and Chris Muenzer present Haselmeier’s innovative approach to the development of reconstitution devices that allow easy and convenient administration of freeze-dried biologics.
Interview with Biocorp’s Arnaud Guillet
INTERVIEW
Arnaud Guillet
Biocorp
Interview with Biocorp’s Arnaud Guillet
In this exclusive interview, Arnaud Guillet of Biocorp talks with ONdrugDelivery about connectivity in the injectables space, sharing some of the insights Biocorp has gained from its decade of experience in developing connected drug delivery devices.
ISO 11608: WHAT THE NEW STANDARD MEANS FOR NIS MANUFACTURERS
INJECTION
Steve Augustyn
Cambridge Design Partnership
ISO 11608: WHAT THE NEW STANDARD MEANS FOR NIS MANUFACTURERS
Steve Augustyn looks at ISO 11608 and what it means for needle-based injection device manufacturers.
REALISING REDUCTIONS IN DEAD VOLUMES WITHIN PREFILLED SYRINGES: A MANUFACTURER’S PERSPECTIVE
PREFILLED SYRINGES
Enrico Barichello
Stevanato Group
REALISING REDUCTIONS IN DEAD VOLUMES WITHIN PREFILLED SYRINGES: A MANUFACTURER’S PERSPECTIVE
Enrico Barichello considers the benefits of prefilled syringes, including cost and waste reduction, and looks at the impact and challenges of dead volume within the syringe.
SILICONE-OIL-FREE, COATING-FREE, TUNGSTEN-FREE PREFILLABLE SYRINGES
PREFILLED SYRINGES
Taras Bredel
Injecto a/s
SILICONE-OIL-FREE, COATING-FREE, TUNGSTEN-FREE PREFILLABLE SYRINGES
Taras Bredel and Bernd Zeiss present the studies, development, performance and benefits of the Injecto lubrigone plunger stopper combined with the Gerresheimer RTF® glass syringe – a silicone-oil-free, coating-free, tungsten-free, low-particle prefilled syringe solution for sensitive drug products.
UNLIMITED POSSIBILITIES BY USING A GAS-PRODUCING DRY CELL
INJECTION
Marc Beutler
simatec
UNLIMITED POSSIBILITIES BY USING A GAS-PRODUCING DRY CELL
Marc Beutler and Matthias Meier discuss the myriad advantages of using a gas-producing dry cell as a drive system for injectable drug delivery devices, as compared with spring-based and electromechanical drives.
A HIGH-QUALITY AND ROBUST SAFETY SYSTEM FOR HIGH-VOLUME BIOLOGICS AT HOME
PREFILLED SYRINGES
Audrey Chandra
Nemera
A HIGH-QUALITY AND ROBUST SAFETY SYSTEM FOR HIGH-VOLUME BIOLOGICS AT HOME
Audrey Chandra and Cécile Gross discuss Nemera’s development of a new product for the safe delivery of high-volume biologics at home.
REACHING A NEW ZENITH IN PROTECTING LARGER-VOLUME SENSITIVE MOLECULES, FROM FILLING TO SELF-ADMINISTRATION
PREFILLED SYRINGES
Victoria Morgan
West Pharmaceutical Services
REACHING A NEW ZENITH IN PROTECTING LARGER-VOLUME SENSITIVE MOLECULES, FROM FILLING TO SELF-ADMINISTRATION
Victoria Morgan and Eric Kurtz, discuss how West Pharmaceutical Services' Daikyo Crystal Zenith™ insert needle prefilled syringe system meets the needs presented by the healthcare sector’s shift to home-based care and the increasing prevalence of biologics in the pharmaceutical pipeline.
OVERCOMING THE CHALLENGES OF ULTRA-LARGE-VOLUME SUBCUTANEOUS INFUSIONS
INJECTION
Rob Limouze
KORU Medical Systems
OVERCOMING THE CHALLENGES OF ULTRA-LARGE-VOLUME SUBCUTANEOUS INFUSIONS
Rob Limouze looks at the obstacles facing ultra-large-volume subcutaneous infusion drug delivery and highlights how the KORU Freedom infusion system meets these challenges.
AUTOINJECTORS: HISTORICAL ACHIEVEMENTS & COMPELLING NEEDS DRIVING NEXT-GENERATION DEVICES
EXPERT VIEW
Richard Whelton
AUTOINJECTORS: HISTORICAL ACHIEVEMENTS & COMPELLING NEEDS DRIVING NEXT-GENERATION DEVICES
Richard Whelton and Philip Green summarise the history of autoinjectors, highlight success stories to date, review the unmet needs that remain and consider emerging needs that could drive continued innovation in autoinjectors to ensure safety, patient satisfaction and pharma commercial success.
COMPANY SHOWCASE: Owen Mumford Pharmaceutical Services
PREFILLED SYRINGES
Owen Mumford
COMPANY SHOWCASE: Owen Mumford Pharmaceutical Services
Owen Mumford Pharmaceutical Services specialises in the design, development and manufacture of injectable drug delivery systems for the pharma, biotech and generics industries. Its trusted devices are used daily in the delivery of various medications for a multitude of conditions across the globe.
Technology Showcase: I-Platform from CCBio – How to Upgrade a Device in One Platform
INJECTION
Jimmy Fan
CC Bio
Technology Showcase: I-Platform from CCBio – How to Upgrade a Device in One Platform
CCBio showcases its I-Platform injectable drug delivery solution comprising: delivery units, including the electronic, connected Tesla device; containers and adapters; and safety needles.
FROM SIMULATION TO SPRING SATISFACTION
INDUSTRIALISATION
Drew Jelgerhuis
Scherdel Medtec North America
FROM SIMULATION TO SPRING SATISFACTION
Drew Jelgerhuis discusses the power of simulation to enhance a drug delivery device design project, including faster development times and reduced costs.
INDUSTRIALISATION OF PHARMACEUTICAL AND MEDICAL DEVICES IN THE SCIENTIFIC MOULDING APPROACH
INDUSTRIALISATION
Thomas Rudolph
Gerresheimer
INDUSTRIALISATION OF PHARMACEUTICAL AND MEDICAL DEVICES IN THE SCIENTIFIC MOULDING APPROACH
Thomas Rudolph, Markus Reil, Stefan Schumann and Tobias Weigert discuss Gerresheimer’s strategy for managing potential risks across the entire product lifecycle.
INDUSTRIALISATION AND SCALE-UP OF DRUG DELIVERY DEVICES
INDUSTRIALISATION
Dr Barry McDermott
West Pharmaceutical Services
INDUSTRIALISATION AND SCALE-UP OF DRUG DELIVERY DEVICES
Barry McDermott and Shari Krusniak look at the manufacturing processes involved in bringing a new drug delivery system and formulation to market.
EMBRACING OPPORTUNITIES PRESENTED BY DIGITALISATION: USING DATA TO DRIVE PERFORMANCE
INDUSTRIALISATION
Otto Abildgaard
Stevanato Group
EMBRACING OPPORTUNITIES PRESENTED BY DIGITALISATION: USING DATA TO DRIVE PERFORMANCE
Otto Abildgaard and Sebastian Berninger-Lund review the four-stage process Stevanato has developed to bring improvements in time to market through optimised manufacturing.
CONTINUOUS IMPROVEMENT: FROM ABSTRACTION TO REALITY
INDUSTRIALISATION
Tracy Pedreso
SHL Medical
CONTINUOUS IMPROVEMENT: FROM ABSTRACTION TO REALITY
Tracy Pedreso discusses SHL Medical’s strategy for making continuous improvement a reality.
HOLISTIC DEVELOPMENT & INDUSTRIALISATION OF DRUG DELIVERY DEVICES & COMBINATION PRODUCTS
INDUSTRIALISATION
Mark Tunkel
Nemera
HOLISTIC DEVELOPMENT & INDUSTRIALISATION OF DRUG DELIVERY DEVICES & COMBINATION PRODUCTS
Mark Tunkel and Niyati Sapatnekar discuss Nemera’s holistic approach to development and industrialisation.
INTERVIEW: Piyush Agarwal, Tjoapack
INTERVIEW
Piyush Agarwal
INTERVIEW: Piyush Agarwal, Tjoapack
Piyush Agarwal talks with ONdrugDelivery about the current state of the injectable pharmaceuticals market and how working with a specialist contract packaging organisation can help pharma companies navigate their product through this rapidly evolving sector and deliver their product to market on time.
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