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GI/ORAL

GI/ORAL
CHALLENGES AND ACHIEVEMENTS OF TIO2 REPLACEMENT IN HARD CAPSULES
Susana Ecenarro Probst looks at the issues arising in replacing TiO2 in hard capsules and introduces Qualicaps' alternative hard capsule formulation.
GI/ORAL
POWDER CHARACTERISATION FOR PHARMACEUTICALS: BEYOND STANDARDS
Aurélien Neveu, Marco Lupo and Filip Francqui discuss the limitations of current standardised procedures for assessing the properties of pharmaceutical powders and how Granutools’ instruments – GranuPack and GranuHeap – offer a significant improvement.
TREATING THE NEXT GENERATION: THE UNTAPPED POTENTIAL OF ORALLY DISPERSIBLE FILMS
GI/ORAL
Dr Keat Theng Chow
Roquette
TREATING THE NEXT GENERATION: THE UNTAPPED POTENTIAL OF ORALLY DISPERSIBLE FILMS
Keat Theng Chow explores the latest scientific thinking on orally dispersible film formulation, and how these advancements could open a new chapter in paediatric patient compliance.
PRODUCT SHOWCASE: Optimising Gastric Resistance in Complex Oral Drug Products with Novel, Functional, Ready-To-Fill Capsules
GI/ORAL
Dr Bettina Hölzer
Evonik
PRODUCT SHOWCASE: Optimising Gastric Resistance in Complex Oral Drug Products with Novel, Functional, Ready-To-Fill Capsules
Evonik showcases its novel, functional, ready-to-fill capsules portfolio, EUDRACAP®, explaining how its role in optimising gastric resistance in complex oral drug products.
STRATEGIES FOR STREAMLINING THE DEVELOPMENT OF COMPLEX ORAL DRUG PRODUCTS
GI/ORAL
Dr Aruna Railkar
Quotient Sciences
STRATEGIES FOR STREAMLINING THE DEVELOPMENT OF COMPLEX ORAL DRUG PRODUCTS
Aruna Railkar presents three case studies – one involving solubility enhancement, one modified release, and a paediatric dosage form – to illustrate the formulation challenges in complex drug programmes.
MODIFIED-RELEASE MICROSPHERES: MAXIMISING COATING INTEGRITY AND OPTIMISING RELEASE
EXPERT VIEW
Dr Jonathan Cape
MODIFIED-RELEASE MICROSPHERES: MAXIMISING COATING INTEGRITY AND OPTIMISING RELEASE
Jonathan Cape discusses development considerations and workflows to select optimal enteric coat weights for modified release microspheres – balancing performance considerations with API stability and the excipient burden to patients.
INCREASE PRODUCTION SUCCESS THROUGH TABLET DESIGN TECHNIQUES
EXPERT VIEW
Richard Ball
INCREASE PRODUCTION SUCCESS THROUGH TABLET DESIGN TECHNIQUES
Richard Ball considers the important features of tablet design and discusses its importance to the mass production of tablets.
HARD CAPSULES: A HOLISTIC APPROACH FOR ORAL DRUG DELIVERY AND FORMULATION
EXPERT VIEW
Dr Jnanadeva Bhat
HARD CAPSULES: A HOLISTIC APPROACH FOR ORAL DRUG DELIVERY AND FORMULATION
Jnanadeva Bhat and Manali Dalvi discuss how advances in capsule technology as an oral drug delivery method have opened up new avenues for the development of more effective and patient-friendly drugs.
AN AIRLESS SPRAY NOZZLE TO PRODUCE A FINE AND SOFT MIST
SKIN
Dr Claire Authesserre
Eveon
AN AIRLESS SPRAY NOZZLE TO PRODUCE A FINE AND SOFT MIST
Claire Authesserre and Florian Corne discuss the current challenges faced by the topical spray-based delivery of therapeutics and how EVEON’s Ad-Mist™ spray nozzle overcomes these challenges to harness the potential of this delivery route.
NEXT-GENERATION CAPSULE FILLING: MG2 AND THE DM² PROJECT
INDUSTRIALISATION
MG2
NEXT-GENERATION CAPSULE FILLING: MG2 AND THE DM² PROJECT
MG2 introduces the UK Made Smarter Innovation - Digital Medicine Manufacturing (DM²) Research Centre, which it has recently joined as an industrial partner, and describes how it will develop an AI-driven microscale capsule filling system for the selection of formulation and process parameters. 
ROUNDTABLE: TRENDS AND INNOVATIONS IN ORAL DRUG DELIVERY
ROUNDTABLE
Michael Morgan
Lonza
ROUNDTABLE: TRENDS AND INNOVATIONS IN ORAL DRUG DELIVERY
Michael Morgen of Lonza Bend, Torkel Gren of Recipharm, and Yogesh Sadhale of Metrics Contract Services, discuss the current trends and innovations influencing oral drug delivery development and what their respective companies can offer to pharma in this space.
INFLUENCE OF ADDITIVES ON THE ELECTROSTATIC CHARGE BUILD-UP OF EXCIPIENTS
GI/ORAL
Dr Aurelien Neveu
Granutools
INFLUENCE OF ADDITIVES ON THE ELECTROSTATIC CHARGE BUILD-UP OF EXCIPIENTS
Aurélien Neveu, Devang Patel and Filip Francqui present a study investigating the influence of additives on the tribocharging behaviour of two excipients using Granutools’ GranuCharge instrument.
NANOENCAPSULATION: A NEW ERA FOR ORAL SOLID DOSAGE FORMS
GI/ORAL
Oksana Lemasson
Skyepharma Production
NANOENCAPSULATION: A NEW ERA FOR ORAL SOLID DOSAGE FORMS
Oksana Lemasson, Sandrine Bourgeois and Vanessa Bourgeaux discuss the performance of the NanoMicS platform for the oral administration of nanoparticles.
FORMULATING SUPERIOR ORAL SUSPENSIONS FOR BETTER PATIENT COMPLIANCE
EXPERT VIEW
Rina Chokshi
FORMULATING SUPERIOR ORAL SUSPENSIONS FOR BETTER PATIENT COMPLIANCE
Rina Chokshi and Dago Caceres discuss how leveraging key ingredients in oral suspensions can enhance stability and sensory attributes, as well as encourage patient compliance.
ADVANCEMENTS AND EVOLUTION OF POWER SOURCES IN DRUG DELIVERY
INJECTION
Bill Welch
Picocyl
ADVANCEMENTS AND EVOLUTION OF POWER SOURCES IN DRUG DELIVERY
William Welch considers the evolution of compressed gas alternatives to spring power for single-use drug delivery devices.
CAPSULES: CLASSIC DRUG DELIVERY FORM HOLDS POTENTIAL FOR SUSTAINABLE DELIVERY
EXPERT VIEW
Dr Jnanadeva Bhat
CAPSULES: CLASSIC DRUG DELIVERY FORM HOLDS POTENTIAL FOR SUSTAINABLE DELIVERY
Jnanadeva Bhat and Anita Solanki discuss the role that hard capsules are able to play in delivering a more sustainable pharmaceutical industry, both as an oral solid dosage form and in dry powder inhalers.
The Secrets of Solubility Enhancement Success with EUDRAGIT<sup>®</sup> Carriers
GI/ORAL
Dr Jessica Mueller-Albers
Evonik
The Secrets of Solubility Enhancement Success with EUDRAGIT® Carriers
Jessica Mueller-Albers discusses how Evonik’s EUDRAGIT® functional polymers can enhance drug solubility and permeability, with a focus on carriers, screening tools and manufacturing processes.
REMOVING CLINICAL TRIAL BIAS WITH OVER-ENCAPSULATION
GI/ORAL
Frédérique Bordes-Picard
Lonza
REMOVING CLINICAL TRIAL BIAS WITH OVER-ENCAPSULATION
Frédérique Bordes-Picard, Julien Lamps and Stephen Rode discuss the considerations to take into account when using over-encapsulation to blind clinical trials, including the advantages of hydroxypropyl methylcellulose over gelatin as a material.
GASTRIC FLOATING MICROCAPSULES FOR THE MANAGEMENT OF PARKINSON’S DISEASE
EARLY INSIGHT
Dr Sashi Kesavapany
LiberaTx
GASTRIC FLOATING MICROCAPSULES FOR THE MANAGEMENT OF PARKINSON’S DISEASE
Kaarunya Sampathkumar, Joachim Loo and Sashi Kesavapany discuss current treatments for Parkinson’s disease and introduce an extended-releasing technology for polypharmacy oral formulations.
NANOPARTICLE ENGINEERING AND 3DP DELIVERY FOR GAME-CHANGING ORAL THERAPEUTICS
GI/ORAL
Niklas Sandler
Nanoform
NANOPARTICLE ENGINEERING AND 3DP DELIVERY FOR GAME-CHANGING ORAL THERAPEUTICS
Niklas Sandler and Thomas West consider the technological advances in nanoparticle engineering that can improve the bioavailability and delivery of oral therapeutics.
FORMULATION SOLUTION FOR MOISTURE-SENSITIVE DRUGS
GI/ORAL
Laura Canalejas
Qualicaps
FORMULATION SOLUTION FOR MOISTURE-SENSITIVE DRUGS
Laura Canalejas outlines the benefits of Quali-V® Extra Dry – a hypromellose capsule designed for moisture-sensitive formulations.
SMARTER MEDICINES TO SECURE PRODUCTS AND PROMOTE PATIENT ENGAGEMENT
GI/ORAL
Gary Pond
Colorcon
SMARTER MEDICINES TO SECURE PRODUCTS AND PROMOTE PATIENT ENGAGEMENT
Gary Pond looks at digital authentication and discusses how on-dose microtaggants can provide a high level of security in authenticating tablets and capsules in the fight against counterfeit products.
ADDRESSING ONGOING AND NEW BIOAVAILABILITY CHALLENGES
EXPERT VIEW
Dr Stephanie Emory
ADDRESSING ONGOING AND NEW BIOAVAILABILITY CHALLENGES
Stephanie Emory explores the pros and cons of various technologies for enhancing solubility and bioavailability for oral drug formulations. Further, Dr Emory draws on her experience as a reviewer at the US FDA to discuss how developers can view the FDA as a partner to aid success when leveraging innovative approaches.
PRODUCT SHOWCASE: Evonik’s newly launched EUDRACAP™ functional, ready-to-fill capsules
GI/ORAL
Evonik
PRODUCT SHOWCASE: Evonik’s newly launched EUDRACAP™ functional, ready-to-fill capsules
Evonik introduces EUDRACAP™, its newly launched platform of functional ready-to-fill HPMC capsules, which helps optimise release profile, protects sensitive active ingredients, and speeds time to market.
ANALYTICAL TECHNIQUES FOR THE FORMULATION OF GASTRORETENTIVE TABLETS
EXPERT VIEW
Jamie Clayton
ANALYTICAL TECHNIQUES FOR THE FORMULATION OF GASTRORETENTIVE TABLETS
Jamie Clayton, Phil Bone and Kyu Mok Hwang discuss the value of analyses such as mercury porosimetry and powder rheology in characterising excipients for gastroretentive tablet formulation, and go on to detail a case study investigating polymer excipients for a novel bilayer floating tablet.
LINKING THE “D” & “M” IN CDMO
EXPERT VIEW
Mr John Ross
LINKING THE “D” & “M” IN CDMO
John Ross looks at the role of CDMOs in product development through to commercialisation and considers the benefits of consolidated “DM” models.
INTERVIEW WITH STEVE AMOUSSOU-GUENOU, ROQUETTE
INTERVIEW
Steve Amoussou-Guenou
Roquette
INTERVIEW WITH STEVE AMOUSSOU-GUENOU, ROQUETTE
In this interview, Steve Amoussou-Guenou discusses how Roquette developed the LYCAGEL™ system and how this plant-based alternative compares with traditional gelatin softgel capsules.
INTRODUCING ISOSORBIDE: A SUSTAINABLE, SAFE, HIGH-PERFORMANCE, PLANT-BASED FEEDSTOCK FOR PACKAGING
SUSTAINABILITY
Jiae Kim
Roquette
INTRODUCING ISOSORBIDE: A SUSTAINABLE, SAFE, HIGH-PERFORMANCE, PLANT-BASED FEEDSTOCK FOR PACKAGING
Jiae Kim introduces isosorbide, a plant starch-derived diol made from renewable feedstock that has wide ranging applications across polymer materials for a variety of industries.
ONE-STOP SHOP FOR TOTAL MIXING SOLUTIONS FOR PHARMACEUTICAL MANUFACTURERS
INDUSTRIALISATION
Bert Dekens
Hosokawa Micron BV
ONE-STOP SHOP FOR TOTAL MIXING SOLUTIONS FOR PHARMACEUTICAL MANUFACTURERS
Bert Dekens discusses Hosokawa Micron's offering for pharmaceutical powder mixing, including the Cyclomix high-shear mixer and the Nauta low-shear mixer, and how the company’s technology solutions take a broader approach to the full mixing process than simply providing a mixing machine.
SUSTAINABLE PHARMACEUTICALS CAN OUTPERFORM THROUGH NATURALLY DERIVED INGREDIENTS & DEEP EXPERTISE
EXPERT VIEW
Rina Chokshi
SUSTAINABLE PHARMACEUTICALS CAN OUTPERFORM THROUGH NATURALLY DERIVED INGREDIENTS & DEEP EXPERTISE
Rina Chokshi discusses the benefits of naturally derived, sustainable ingredients and their benefits to the environment and pharmaceutical industry.
LEADING PHARMACEUTICAL DEVELOPMENT IN A SUSTAINABLE WAY – SKYEPHARMA’S EXAMPLE
SUSTAINABILITY
Dr Aline Moulin
Skyepharma Production
LEADING PHARMACEUTICAL DEVELOPMENT IN A SUSTAINABLE WAY – SKYEPHARMA’S EXAMPLE
Aline Moulin and Laurent Rigaudeau discuss how Skyepharma fulfils its sustainable development policy through its technologies and processes.
NANOTECHNOLOGY: A PATHWAY FOR SUSTAINABLE INNOVATION IN DRUG DEVELOPMENT
SUSTAINABILITY
Andrea Cusack
leon-nanodrugs
NANOTECHNOLOGY: A PATHWAY FOR SUSTAINABLE INNOVATION IN DRUG DEVELOPMENT
Andrea Cusack discusses how, by using bottom-up nanotechnology techniques, efficiencies can be found both in the development of new chemical entities and in the repurposing of existing drugs, and how these efficiencies translate into reduced energy requirements and therefore more sustainable industry practices.
ROUNDTABLE: JEREMY DRUMMOND, MEDPHARM; STEPHEN RODE, LONZA; AND TORKEL GREN, RECIPHARM
ROUNDTABLE
Dr Jeremy Drummond
ROUNDTABLE: JEREMY DRUMMOND, MEDPHARM; STEPHEN RODE, LONZA; AND TORKEL GREN, RECIPHARM
In this roundtable discussion, Jeremy Drummond, Stephen Rode and Torkel Gren discuss trends with different drug dosage forms for different routes of administration, the rise of patient centricity including the shift from the blockbuster model to more tailored products.
TFF AND UNION AGREE LICENSING PACT FOR TFF TECHNOLOGY WITH NICLOSAMIDE FOR THE TREATMENT OF COVID-19
COVID-19 NEWS
TFF AND UNION AGREE LICENSING PACT FOR TFF TECHNOLOGY WITH NICLOSAMIDE FOR THE TREATMENT OF COVID-19
UNION therapeutics has acquired an option to a worldwide, exclusive licence to TFF Pharmaceuticals' Thin Film Freezing (TFF) technology, in combination with niclosamide, covering oral and inhalation formulations, potentially for covid-19, as well as other niclosamide-based therapies.
MAKING MEDICINE EASIER TO TAKE
GI/ORAL
Graeme Macleod
SPI Pharma
MAKING MEDICINE EASIER TO TAKE
Graeme Macleod and Wayne Camarco discuss the rational design of excipients to meet the needs of patient-centric formulations.
FORMULATION FLEXIBILITY WITH NEW ERA HPMC CAPSULES
GI/ORAL
Sanjay Powale
ACG
FORMULATION FLEXIBILITY WITH NEW ERA HPMC CAPSULES
Sanjay Powale, Anita Solanki and Dorene Almeida discuss the benefits of HPMC capsules in overcoming challenges faced by traditional gelatin capsules.
THE FLOWABILITY OF LACTOSE POWDERS TO OPTIMISE TABLETING PROCESSES
GI/ORAL
Dr Aurelien Neveu
Granutools
THE FLOWABILITY OF LACTOSE POWDERS TO OPTIMISE TABLETING PROCESSES
Aurélien Neveu, Pauline Janssen and Geoffroy Lumay discuss how new measurement methods can help gain a better understanding of the flowability of lactose powders – a necessary step for future improvement of oral delivery systems.
NANOPARTICLE ENGINEERING: REVOLUTIONISING ORAL DRUG DEVELOPMENT & DELIVERY
GI/ORAL
Dr Satu Lakio
Nanoform
NANOPARTICLE ENGINEERING: REVOLUTIONISING ORAL DRUG DEVELOPMENT & DELIVERY
Satu Lakio and Niklas Sandler discuss the benefits of nanoparticle engineering technology as a means of improving the bioavailability and solubility of drug compounds.
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