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Pulmonary & Nasal Drug Delivery127

Issue No #127 Nov 2021 November 17th, 2021

Inside the magazine

WAITING FOR THE OUTBREATH – WHAT CAN COVID-19 BIOAEROSOL RESEARCH TELL US ABOUT INHALABLE DRUG DELIVERY?

Cambridge Design Partnership

WAITING FOR THE OUTBREATH – WHAT CAN COVID-19 BIOAEROSOL RESEARCH TELL US ABOUT INHALABLE DRUG DELIVERY?

Deborah Norris, Mark Allen, Karl Hewson and Karla Sanchez, discuss how the covid-19 pandemic has spurred research in the pulmonary space, which suggests that a patient-tailored approach based on their individual lung characteristics, facilitated by advanced technology, could improve patient health outcomes and quality of life.

CHARACTERISING WALL THICKNESS OF QUALI-V<sup>®</sup>-I CAPSULES & ITS EFFECT ON CAPSULE PUNCTURE BY A DPI PIN

CHARACTERISING WALL THICKNESS OF QUALI-V^®-I CAPSULES & ITS EFFECT ON CAPSULE PUNCTURE BY A DPI PIN

Siamac Parker, Sion Coulman, Prof James Birchall alongside Susana Ecenarro and Mahmoud Farag, present a study that uses optical coherence tomography to characterise the wall thickness of capsules at the dome position and investigates the importance of controlling the dome thickness of hard-shell capsules to be used in a dry powder inhaler.

ADDRESSING THE CHALLENGES OF NASAL BIOTHERAPEUTIC DRUG DELIVERY

ADDRESSING THE CHALLENGES OF NASAL BIOTHERAPEUTIC DRUG DELIVERY

Robert Lee discusses the benefits of administering drugs to the nasal cavity, as well as the main challenges in formulation for this route and the strategies that can be applied to overcome them.

MAKING THE CONNECTION BETWEEN EFFICACY AND ENVIRONMENTAL SUSTAINABILITY

Andreas Meliniotis

MAKING THE CONNECTION BETWEEN EFFICACY AND ENVIRONMENTAL SUSTAINABILITY

Andreas Meliniotis looks at the factors that should be considered when designing devices with a view to sustainable connectivity.

POWDER CHARACTERISATION: A CRITICAL TOOL FOR THE EVOLUTION OF INHALED DRUG DELIVERY

POWDER CHARACTERISATION: A CRITICAL TOOL FOR THE EVOLUTION OF INHALED DRUG DELIVERY

Jamie Clayton, Joana Pinto and Sarah Zellnitz discuss the benefits of multi-faceted powder characterisation in dry powder inhalation formulations and how it can support efforts to achieve net zero emissions.

LEVERAGING HUMAN FACTORS TO DEVELOP PATIENT-CENTRIC INHALERS

Raphaële Audibert

LEVERAGING HUMAN FACTORS TO DEVELOP PATIENT-CENTRIC INHALERS

Raphaële Audibert, Mark Tunkel and Manuela Basso look at the role patient-centricity has to play in the development of inhalers to treat chronic respiratory diseases.

NUMERICAL SIMULATIONS FOR INHALATION PRODUCT DEVELOPMENT: ACHIEVEMENTS AND CURRENT LIMITATIONS

Dr Andrea Benassi

NUMERICAL SIMULATIONS FOR INHALATION PRODUCT DEVELOPMENT: ACHIEVEMENTS AND CURRENT LIMITATIONS

Andrea Benassi and Ciro Cottini discuss the current state of CFD and DEM computational modelling, how it is used to improve inhaler design and manufacturing, and what the current limitations of this technology are, as well as how those limitations may be overcome.

IMPROVING IN VITRO TEST METHODS FOR NASAL DRUG PRODUCTS

Copley Scientific

IMPROVING IN VITRO TEST METHODS FOR NASAL DRUG PRODUCTS

Mark Copley and Anna Sipitanou look at how in vitro testing is being refined for greater repeatability to maximise its value as a low-cost tool for product development, including an assessment of the role of automation in improving the sensitivity of in vitro testing.

TOWARDS A MORE SUSTAINABLE FUTURE WITH pMDI SOLUTIONS

TOWARDS A MORE SUSTAINABLE FUTURE WITH pMDI SOLUTIONS

Howard Burnett, Chris Baron and Jay Bhogaita summarise the findings of a recent forum that looked at the development of more sustainable pressurised metered dose inhalers.

DELIVERING ON THE PROMISES OF INTRANASAL VACCINATION

DELIVERING ON THE PROMISES OF INTRANASAL VACCINATION

Julie Suman and Nektaria Karavas review intranasal delivery as a method of vaccine administration and consider the challenges and benefits of intranasal delivery.

DELIVERING SUSPENSIONS WITH MESH TECHNOLOGY

Edgar Hernan Cuevas Brun

HCmed Innovations

DELIVERING SUSPENSIONS WITH MESH TECHNOLOGY

Edgar Hernan Cuevas Brun and Yuan-Ming Hsu discuss the performance of mesh nebulisers for the delivery of suspensions in inhalation therapy.

ROUNDTABLE: CAPSULE-BASED DRY POWDER INHALERS

Frédérique Bordes-Picard

ROUNDTABLE: CAPSULE-BASED DRY POWDER INHALERS

Frédérique Bordes-Picard of Lonza, Marco Franza of Berry, Mirjam Kobler of Meggle, and Marco Laackmann of Harro Höfliger, discuss the accelerating development potential of capsule-based dry powder inhalers (DPIs) and the potential of these effective and efficient drug delivery devices in the modern drug delivery market.

TRANSFORMING DRUG DELIVERY WITH SYNERGISTIC WORKING

TRANSFORMING DRUG DELIVERY WITH SYNERGISTIC WORKING

Bas van Driel discusses how expert collaborations can help develop a knowledge base to transform drug delivery and manufacturing. He shares how recent collaborative research projects involving lactose-based dry powder inhalation formulations, with and without magnesium stearate and lactose as an excipient in 3D tablet printing, have done just that.

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